DetoxFungiV1, Main, Exploration, bibRecord, 000679

UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences.

Identifieur interne : 000679 ( Main/Exploration ); précédent : 000678; suivant : 000680

UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences.

Source :

International journal for parasitology. Drugs and drug resistance [ 2211-3207 ] ; 2018.

RBID : pubmed:30293057

Descripteurs français

KwdFr :
- Animaux (MeSH), Anthelminthiques (pharmacologie), Benzimidazoles (pharmacologie), Caenorhabditis elegans (enzymologie), Caenorhabditis elegans (génétique), Cartographie chromosomique (MeSH), Expression des gènes (MeSH), Facteurs sexuels (MeSH), Famille multigénique (MeSH), Glycosylation (MeSH), Glycosyltransferase (classification), Glycosyltransferase (composition chimique), Glycosyltransferase (génétique), Haemonchus (effets des médicaments et des substances chimiques), Haemonchus (enzymologie), Haemonchus (génétique), Maladies des ovins (parasitologie), Ovis (MeSH), Phylogenèse (MeSH), Résistance aux substances (génétique), Uridine diphosphate (génétique).
MESH :
- classification : Glycosyltransferase.
- composition chimique : Glycosyltransferase.
- effets des médicaments et des substances chimiques : Haemonchus.
- enzymologie : Caenorhabditis elegans, Haemonchus.
- génétique : Caenorhabditis elegans, Glycosyltransferase, Haemonchus, Résistance aux substances, Uridine diphosphate.
- parasitologie : Maladies des ovins.
- pharmacologie : Anthelminthiques, Benzimidazoles.
- Animaux, Cartographie chromosomique, Expression des gènes, Facteurs sexuels, Famille multigénique, Glycosylation, Ovis, Phylogenèse.

English descriptors

KwdEn :
- Animals (MeSH), Anthelmintics (pharmacology), Benzimidazoles (pharmacology), Caenorhabditis elegans (enzymology), Caenorhabditis elegans (genetics), Chromosome Mapping (MeSH), Drug Resistance (genetics), Gene Expression (MeSH), Glycosylation (MeSH), Glycosyltransferases (chemistry), Glycosyltransferases (classification), Glycosyltransferases (genetics), Haemonchus (drug effects), Haemonchus (enzymology), Haemonchus (genetics), Multigene Family (MeSH), Phylogeny (MeSH), Sex Factors (MeSH), Sheep (MeSH), Sheep Diseases (parasitology), Uridine Diphosphate (genetics).
MESH :
- chemical , chemistry : Glycosyltransferases.
- chemical , classification : Glycosyltransferases.
- chemical , genetics : Glycosyltransferases, Uridine Diphosphate.
- chemical , pharmacology : Anthelmintics, Benzimidazoles.
- drug effects : Haemonchus.
- enzymology : Caenorhabditis elegans, Haemonchus.
- genetics : Caenorhabditis elegans, Drug Resistance, Haemonchus.
- parasitology : Sheep Diseases.
- Animals, Chromosome Mapping, Gene Expression, Glycosylation, Multigene Family, Phylogeny, Sex Factors, Sheep.

Abstract

UDP-glycosyltransferases (UGT), catalysing conjugation of UDP-activated sugar donors to small lipophilic chemicals, are widespread in living organisms from bacteria to fungi, plant, or animals. The progress of genome sequencing has enabled an assessment of the UGT multigene family in Haemonchus contortus (family Trichostrongylidae, Nematoda), a hematophagous gastrointestinal parasite of small ruminants. Here we report 32 putative UGT genes divided into 15 UGT families. Phylogenetic analysis in comparison with UGTs from Caenorhabditis elegans, a free-living model nematode, revealed several single member homologues, a lack of the dramatic gene expansion seen in C. elegans, but also several families (UGT365, UGT366, UGT368) expanded in H. contortus only. The assessment of constitutive UGT mRNA expression in H. contortus adults identified significant differences between females and males. In addition, we compared the expression of selected UGTs in the drug-sensitive ISE strain to two benzimidazole-resistant strains, IRE and WR, with different genetic backgrounds. Constitutive expression of UGT368B2 was significantly higher in both resistant strains than in the sensitive strain. As resistant strains were able to deactivate benzimidazole anthelmintics via glycosylation more effectively then the sensitive strain, UGT368B2 enhanced constitutive expression might contribute to drug resistance in H. contortus.

DOI: 10.1016/j.ijpddr.2018.09.005
PubMed: 30293057
PubMed Central: PMC6174829

Affiliations:

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to stream Main, to step Corpus: 000690
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Le document en format XML

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<author><name sortKey="Raisova Stuchlikova, Lucie" sort="Raisova Stuchlikova, Lucie" uniqKey="Raisova Stuchlikova L" first="Lucie" last="Raisová Stuchlíková">Lucie Raisová Stuchlíková</name>
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<author><name sortKey="Nguyen, Linh Thuy" sort="Nguyen, Linh Thuy" uniqKey="Nguyen L" first="Linh Thuy" last="Nguyen">Linh Thuy Nguyen</name>
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<country xml:lang="fr">République tchèque</country>
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<author><name sortKey="Kellerova, Pavlina" sort="Kellerova, Pavlina" uniqKey="Kellerova P" first="Pavlína" last="Kellerová">Pavlína Kellerová</name>
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<author><name sortKey="Lamka, Ji" sort="Lamka, Ji" uniqKey="Lamka J" first="Ji" last="Lamka">Ji Lamka</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Heyrovského 1203, CZ-500 05, Hradec Králové, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
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<author><name sortKey="Varady, Marian" sort="Varady, Marian" uniqKey="Varady M" first="Marián" last="Várady">Marián Várady</name>
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<author><name sortKey="Skalova, Lenka" sort="Skalova, Lenka" uniqKey="Skalova L" first="Lenka" last="Skálová">Lenka Skálová</name>
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<series><title level="j">International journal for parasitology. Drugs and drug resistance</title>
<idno type="eISSN">2211-3207</idno>
<imprint><date when="2018" type="published">2018</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Anthelmintics (pharmacology)</term>
<term>Benzimidazoles (pharmacology)</term>
<term>Caenorhabditis elegans (enzymology)</term>
<term>Caenorhabditis elegans (genetics)</term>
<term>Chromosome Mapping (MeSH)</term>
<term>Drug Resistance (genetics)</term>
<term>Gene Expression (MeSH)</term>
<term>Glycosylation (MeSH)</term>
<term>Glycosyltransferases (chemistry)</term>
<term>Glycosyltransferases (classification)</term>
<term>Glycosyltransferases (genetics)</term>
<term>Haemonchus (drug effects)</term>
<term>Haemonchus (enzymology)</term>
<term>Haemonchus (genetics)</term>
<term>Multigene Family (MeSH)</term>
<term>Phylogeny (MeSH)</term>
<term>Sex Factors (MeSH)</term>
<term>Sheep (MeSH)</term>
<term>Sheep Diseases (parasitology)</term>
<term>Uridine Diphosphate (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Anthelminthiques (pharmacologie)</term>
<term>Benzimidazoles (pharmacologie)</term>
<term>Caenorhabditis elegans (enzymologie)</term>
<term>Caenorhabditis elegans (génétique)</term>
<term>Cartographie chromosomique (MeSH)</term>
<term>Expression des gènes (MeSH)</term>
<term>Facteurs sexuels (MeSH)</term>
<term>Famille multigénique (MeSH)</term>
<term>Glycosylation (MeSH)</term>
<term>Glycosyltransferase (classification)</term>
<term>Glycosyltransferase (composition chimique)</term>
<term>Glycosyltransferase (génétique)</term>
<term>Haemonchus (effets des médicaments et des substances chimiques)</term>
<term>Haemonchus (enzymologie)</term>
<term>Haemonchus (génétique)</term>
<term>Maladies des ovins (parasitologie)</term>
<term>Ovis (MeSH)</term>
<term>Phylogenèse (MeSH)</term>
<term>Résistance aux substances (génétique)</term>
<term>Uridine diphosphate (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Glycosyltransferases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="classification" xml:lang="en"><term>Glycosyltransferases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glycosyltransferases</term>
<term>Uridine Diphosphate</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anthelmintics</term>
<term>Benzimidazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="fr"><term>Glycosyltransferase</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Glycosyltransferase</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Haemonchus</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Haemonchus</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Caenorhabditis elegans</term>
<term>Haemonchus</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Caenorhabditis elegans</term>
<term>Haemonchus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Caenorhabditis elegans</term>
<term>Drug Resistance</term>
<term>Haemonchus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Caenorhabditis elegans</term>
<term>Glycosyltransferase</term>
<term>Haemonchus</term>
<term>Résistance aux substances</term>
<term>Uridine diphosphate</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Maladies des ovins</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Sheep Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anthelminthiques</term>
<term>Benzimidazoles</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Chromosome Mapping</term>
<term>Gene Expression</term>
<term>Glycosylation</term>
<term>Multigene Family</term>
<term>Phylogeny</term>
<term>Sex Factors</term>
<term>Sheep</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cartographie chromosomique</term>
<term>Expression des gènes</term>
<term>Facteurs sexuels</term>
<term>Famille multigénique</term>
<term>Glycosylation</term>
<term>Ovis</term>
<term>Phylogenèse</term>
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<front><div type="abstract" xml:lang="en">UDP-glycosyltransferases (UGT), catalysing conjugation of UDP-activated sugar donors to small lipophilic chemicals, are widespread in living organisms from bacteria to fungi, plant, or animals. The progress of genome sequencing has enabled an assessment of the UGT multigene family in Haemonchus contortus (family Trichostrongylidae, Nematoda), a hematophagous gastrointestinal parasite of small ruminants. Here we report 32 putative UGT genes divided into 15 UGT families. Phylogenetic analysis in comparison with UGTs from Caenorhabditis elegans, a free-living model nematode, revealed several single member homologues, a lack of the dramatic gene expansion seen in C. elegans, but also several families (UGT365, UGT366, UGT368) expanded in H. contortus only. The assessment of constitutive UGT mRNA expression in H. contortus adults identified significant differences between females and males. In addition, we compared the expression of selected UGTs in the drug-sensitive ISE strain to two benzimidazole-resistant strains, IRE and WR, with different genetic backgrounds. Constitutive expression of UGT368B2 was significantly higher in both resistant strains than in the sensitive strain. As resistant strains were able to deactivate benzimidazole anthelmintics via glycosylation more effectively then the sensitive strain, UGT368B2 enhanced constitutive expression might contribute to drug resistance in H. contortus.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30293057</PMID>
<DateCompleted><Year>2019</Year>
<Month>01</Month>
<Day>30</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>01</Month>
<Day>30</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2211-3207</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<Issue>3</Issue>
<PubDate><Year>2018</Year>
<Month>12</Month>
</PubDate>
</JournalIssue>
<Title>International journal for parasitology. Drugs and drug resistance</Title>
<ISOAbbreviation>Int J Parasitol Drugs Drug Resist</ISOAbbreviation>
</Journal>
<ArticleTitle>UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences.</ArticleTitle>
<Pagination><MedlinePgn>420-429</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S2211-3207(18)30086-1</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijpddr.2018.09.005</ELocationID>
<Abstract><AbstractText>UDP-glycosyltransferases (UGT), catalysing conjugation of UDP-activated sugar donors to small lipophilic chemicals, are widespread in living organisms from bacteria to fungi, plant, or animals. The progress of genome sequencing has enabled an assessment of the UGT multigene family in Haemonchus contortus (family Trichostrongylidae, Nematoda), a hematophagous gastrointestinal parasite of small ruminants. Here we report 32 putative UGT genes divided into 15 UGT families. Phylogenetic analysis in comparison with UGTs from Caenorhabditis elegans, a free-living model nematode, revealed several single member homologues, a lack of the dramatic gene expansion seen in C. elegans, but also several families (UGT365, UGT366, UGT368) expanded in H. contortus only. The assessment of constitutive UGT mRNA expression in H. contortus adults identified significant differences between females and males. In addition, we compared the expression of selected UGTs in the drug-sensitive ISE strain to two benzimidazole-resistant strains, IRE and WR, with different genetic backgrounds. Constitutive expression of UGT368B2 was significantly higher in both resistant strains than in the sensitive strain. As resistant strains were able to deactivate benzimidazole anthelmintics via glycosylation more effectively then the sensitive strain, UGT368B2 enhanced constitutive expression might contribute to drug resistance in H. contortus.</AbstractText>
<CopyrightInformation>Copyright © 2018. Published by Elsevier Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Matoušková</LastName>
<ForeName>Petra</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203, CZ-500 05, Hradec Králové, Czech Republic. Electronic address: matousp7@faf.cuni.cz.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lecová</LastName>
<ForeName>Lenka</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University, Studničkova 7, CZ-128 00, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Laing</LastName>
<ForeName>Roz</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, 464 Bearsden Road, Glasgow, Scotland, G61 1QH, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dimunová</LastName>
<ForeName>Diana</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203, CZ-500 05, Hradec Králové, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vogel</LastName>
<ForeName>Heiko</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Max Planck Institute for Chemical Ecology, Department of Entomology, Hans-Knöll-Straße 8, DE-07745, Jena, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Raisová Stuchlíková</LastName>
<ForeName>Lucie</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203, CZ-500 05, Hradec Králové, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nguyen</LastName>
<ForeName>Linh Thuy</ForeName>
<Initials>LT</Initials>
<AffiliationInfo><Affiliation>Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203, CZ-500 05, Hradec Králové, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kellerová</LastName>
<ForeName>Pavlína</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203, CZ-500 05, Hradec Králové, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vokřál</LastName>
<ForeName>Ivan</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Heyrovského 1203, CZ-500 05, Hradec Králové, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lamka</LastName>
<ForeName>Jiří</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Heyrovského 1203, CZ-500 05, Hradec Králové, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Szotáková</LastName>
<ForeName>Barbora</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203, CZ-500 05, Hradec Králové, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Várady</LastName>
<ForeName>Marián</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Institute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, SK-040 01, Košice, Slovakia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Skálová</LastName>
<ForeName>Lenka</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203, CZ-500 05, Hradec Králové, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>BB/M003949/1</GrantID>
<Agency>Biotechnology and Biological Sciences Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>09</Month>
<Day>26</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Int J Parasitol Drugs Drug Resist</MedlineTA>
<NlmUniqueID>101576715</NlmUniqueID>
<ISSNLinking>2211-3207</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000871">Anthelmintics</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001562">Benzimidazoles</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>58-98-0</RegistryNumber>
<NameOfSubstance UI="D014530">Uridine Diphosphate</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>E24GX49LD8</RegistryNumber>
<NameOfSubstance UI="C031000">benzimidazole</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.4.-</RegistryNumber>
<NameOfSubstance UI="D016695">Glycosyltransferases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000871" MajorTopicYN="N">Anthelmintics</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001562" MajorTopicYN="N">Benzimidazoles</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017173" MajorTopicYN="N">Caenorhabditis elegans</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002874" MajorTopicYN="N">Chromosome Mapping</DescriptorName>
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<MeshHeading><DescriptorName UI="D004351" MajorTopicYN="N">Drug Resistance</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015870" MajorTopicYN="N">Gene Expression</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006031" MajorTopicYN="N">Glycosylation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016695" MajorTopicYN="N">Glycosyltransferases</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006189" MajorTopicYN="N">Haemonchus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005810" MajorTopicYN="N">Multigene Family</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010802" MajorTopicYN="Y">Phylogeny</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012756" MajorTopicYN="N">Sheep</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012757" MajorTopicYN="N">Sheep Diseases</DescriptorName>
<QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014530" MajorTopicYN="N">Uridine Diphosphate</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Detoxification</Keyword>
<Keyword MajorTopicYN="Y">Haemonchus contortus</Keyword>
<Keyword MajorTopicYN="Y">Resistance</Keyword>
<Keyword MajorTopicYN="Y">UDP-glycosyltransferase</Keyword>
</KeywordList>
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<Day>26</Day>
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<Month>09</Month>
<Day>17</Day>
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<Day>18</Day>
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UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences.

UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences.

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